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Molecular medicine : how science works
Carlberg, Carsten,
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xxxiv, 700 pages : |
| ISBN: |
9783031271328 |
| Item info: |
1 copy available in RESERVES.
1 copy total in all locations.
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Personal Author:
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Carlberg, Carsten,
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Title:
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Molecular medicine : how science works / Carsten Carlberg, Eunike Velleure, Ferdinand Molnar.
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Physical descrip:
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xxxiv, 700 pages : illustrations (some color) ; 24 cm.
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Contents Note:
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1. The Human Genome and Its Variations -- 2. Gene Expression and Chromatin -- 3. Basal Transcriptional Machinery -- 4. Transcription Factors and Signal Transduction -- 5. A Key Transcription Factor Family: Nuclear Receptors -- 6. DNA Methylation -- Histone Modifications -- 8. Chromatin Remodeling and Organization -- 9. Regulatory Impact of Non-coding RNA -- 10. Genome-Wide Principles of Gene Regulation -- 11. Epigenetics in Development -- 12. Epigenetics and Aging -- 13. Epigenetics and Disease -- 14. Cells and Tissues of the Immune System -- 15. Innate Immunity and Inflammation -- 16. Adaptive Immunity and Antigen Receptor Diversity -- 17. B Cell Immunity: BCRs, Antibodies and Their Effector Functions -- 18. Antigen-Presenting Cells and MHCs -- 19. T Cell Immunity: TCRs and Their Effector Functions -- 20. Immunity to Bacterial Pathogens and the Microbiome -- 21. Immunity to Viral Pathogens and the Virome -- 22. Tolerance and Transplantation Immunology -- 23. Immunological Hypersensitivities: Allergy and Autoimmunity -- 24. Introduction to Cancer -- 25. Oncogenes, Signal Transduction and the Hallmarks of Cancer -- 26. Tumor Suppressor Genes and Cell Fate Control -- 27. Multistep Tumorigenesis and Genome Instability -- 28. Cancer Genomics -- 29. Cancer Epigenomics -- 30. Aging and Cancer -- 31. Tumor Microenvironment -- 32. Metastasis and Cachexia -- 33. Cancer Immunology -- 34. Architecture of Cancer Therapies -- 35. Nutrition and Common Diseases -- 36. Interference of the Human Genome with Nutrients -- 37. Nutritional Epigenetics, Signaling and Aging -- 38. Chronic Inflammation and Metabolic Stress -- 39. Obesity -- 40. Insulin Resistance and Diabetes -- 41. Heart Disease and the Metabolic Syndrome -- 42. Epigenetics, Inflammation and Disease -- 43.
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Summary:
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The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type 2 diabetes, can be explained only to some 20% via a genetic predisposition. We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine. This will provide them with a good basis for their specialized disciplines of modern life science research.
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Subject term:
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Molecular biology.
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Subject term:
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Genetics, Medical
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Added author:
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Velleure, Eunike,
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Added author:
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Molnar, Ferdinand,
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Electronic access:
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http://library.uksw.edu/TOC-PDF/2023/23080014.pdf
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